{"id":158,"date":"2023-12-01T22:48:28","date_gmt":"2023-12-01T13:48:28","guid":{"rendered":"https:\/\/nakano-dm.clinic\/blog\/?p=158"},"modified":"2023-12-01T22:52:23","modified_gmt":"2023-12-01T13:52:23","slug":"post-158","status":"publish","type":"post","link":"https:\/\/nakano-dm.clinic\/blog\/post-158\/","title":{"rendered":"\u534a\u5e74\u306b1\u56de\u306e\u6ce8\u5c04\u3067\u6cbb\u7642\u3067\u304d\u308b\u8102\u8cea\u7570\u5e38\u75c7\u6cbb\u7642\u85ac\u30ec\u30af\u30d3\u30aa\u306b\u3064\u3044\u3066"},"content":{"rendered":"\n<p>\u4e2d\u91ce\u99c5\u524d\u5185\u79d1\u30af\u30ea\u30cb\u30c3\u30af \u7cd6\u5c3f\u75c5\u30fb\u5185\u5206\u6ccc\u5185\u79d1\u306e\u9662\u9577\u306e\u5927\u5ead\u5065\u53f2\u3067\u3059\u3002\u5f53\u30af\u30ea\u30cb\u30c3\u30af\u30db\u30fc\u30e0\u30da\u30fc\u30b8\u306e\u300c<a href=\"https:\/\/nakano-dm.clinic\/dyslipidemia.html\" title=\"\">\u8102\u8cea\u7570\u5e38\u75c7<\/a>\u300d\u3084\u30d6\u30ed\u30b0\u306a\u3069\u3067\u8102\u8cea\u7570\u5e38\u75c7\u306e\u6cbb\u7642\u306e\u91cd\u8981\u6027\u306b\u3064\u3044\u3066\u304a\u8a71\u3057\u3057\u3066\u307e\u3044\u308a\u307e\u3057\u305f\u304c\u3001\u4eca\u56de\u306f\u65b0\u305f\u306a\u8102\u8cea\u7570\u5e38\u75c7\u6cbb\u7642\u85ac\u3067\u3042\u308b\u30ec\u30af\u30d3\u30aa\uff08\u30a4\u30f3\u30af\u30ea\u30b7\u30e9\u30f3\u30ca\u30c8\u30ea\u30a6\u30e0\uff09\u306b\u3064\u3044\u3066\u304a\u8a71\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3000<\/p>\n\n\n\n<p><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"307\" height=\"164\" src=\"https:\/\/nakano-dm.clinic\/blog\/wp-content\/uploads\/2023\/12\/prkk20231122.jpg\" alt=\"\" class=\"wp-image-159\"\/><\/figure>\n<\/div>\n\n\n<p class=\"has-text-align-right\">(\u51fa\u5178\uff1aNOVARTIS \u30db\u30fc\u30e0\u30da\u30fc\u30b8\u3088\u308a)<\/p>\n\n\n\n<p>\u3000<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\u30ec\u30af\u30d3\u30aa\u306f\u3001\u3053\u308c\u307e\u3067\u306b90\u30f6\u56fd\u4ee5\u4e0a\u3067\u627f\u8a8d\u3092\u53d7\u3051\u305f\u85ac\u5264\u3067\u3042\u308a\u3001\u65e5\u672c\u3067\u306f2023\u5e749\u670825\u65e5\u306b\u85ac\u4fa1\u53ce\u8f09\u3055\u308c\u3001\u540c\u5e7411\u670824\u65e5\u306b\u767a\u58f2\u304c\u958b\u59cb\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u85ac\u5264\u306f\u30011\u56de300 mg\u3092\u521d\u56de\u3068\u305d\u306e3\u30f6\u6708\u5f8c\u306b\u76ae\u4e0b\u6ce8\u5c04\u3057\u3001\u305d\u306e\u5f8c\u306f\u534a\u5e74\u306b1\u56de\u306e\u9593\u9694\u3067\u76ae\u4e0b\u6ce8\u5c04\u3057\u307e\u3059\u3002\u5f93\u6765\u306e\u8102\u8cea\u7570\u5e38\u75c7\u6cbb\u7642\u85ac\u3067\u3042\u308b\u30ec\u30d1\u30fc\u30b5\uff08\u30a8\u30dc\u30ed\u30af\u30de\u30d6\uff09\u3068\u540c\u3058\u304f\u3001\u672c\u85ac\u5264\u3082PCSK9\uff08proprotein convertase subtilisin\/kexin type 9\uff09\u3092\u6a19\u7684\u3068\u3057\u305f\u3082\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3000<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>PCSK9\u306f\u3001\u4e3b\u306b\u809d\u81d3\u306eLDL\u53d7\u5bb9\u4f53\u306e\u5206\u89e3\u3092\u4fc3\u9032\u3055\u305b\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u3001\u3053\u306e\u30bf\u30f3\u30d1\u30af\u306f\u8840\u4e2d\u306eLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u6e1b\u3089\u306a\u3044\u3088\u3046\u306b\u8abf\u6574\u3057\u3066\u3044\u307e\u3059\u3002PCSK9\u963b\u5bb3\u85ac\u3067\u3042\u308b\u30ec\u30d1\u30fc\u30b5\u306f\u3001\u6587\u5b57\u901a\u308aPCSK9\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067LDL\u53d7\u5bb9\u4f53\u306e\u5206\u89e3\u3092\u6291\u5236\u3057\u3001\u7d50\u679c\u3068\u3057\u3066\u8840\u4e2d\u306eLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u3092\u8457\u3057\u304f\u6539\u5584\u3055\u305b\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3000<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\u4e00\u65b9\u3001\u30ec\u30af\u30d3\u30aa\u306f\u3001PCSK9\u3092\u751f\u6210\u3059\u308b\u907a\u4f1d\u60c5\u5831\u3092\u6301\u3064mRNA\uff08\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fcRNA\uff09\u3092\u6a19\u7684\u3068\u3057\u305fsiRNA\uff08\u77ed\u9396\u5e72\u6e09RNA\uff09\u88fd\u5264\u3067\u3059\u3002\u30ec\u30af\u30d3\u30aa\u3092\u6295\u4e0e\u3059\u308b\u3068\u809d\u81d3\u306b\u53d6\u308a\u8fbc\u307e\u308c\u3001\u809d\u81d3\u306ePCSK9\u95a2\u9023mRNA\u306e\u5206\u89e3\u304c\u4fc3\u9032\u3055\u308c\u3001\u3053\u308c\u306b\u3088\u3063\u3066LDL\u53d7\u5bb9\u4f53\u304c\u5897\u52a0\u3057\u305d\u306e\u7d50\u679c\u3001\u8840\u4e2dLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u6539\u5584\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3000<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\u305f\u3060\u3057\u3001\u3069\u3061\u3089\u306e\u85ac\u5264\u3082\u8102\u8cea\u7570\u5e38\u75c7\u6cbb\u7642\u306e\u7b2c\u4e00\u9078\u629e\u85ac\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u7b2c\u4e00\u9078\u629e\u85ac\u306f\u3001\u6bd4\u8f03\u7684\u5b89\u4fa1\u3067\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u8c4a\u5bcc\u306a\u30b9\u30bf\u30c1\u30f3\uff08HMG-CoA\u9084\u5143\u9175\u7d20\u963b\u5bb3\u85ac\uff09\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3000<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\u305d\u306e\u30b9\u30bf\u30c1\u30f3\u3092\u6700\u5927\u5bb9\u91cf\u3067\u4f7f\u7528\u3057\u3066\u3082\u52b9\u679c\u304c\u4e0d\u5341\u5206\u3067\u3042\u308b\u304b\u3001\u307e\u305f\u306f\u30b9\u30bf\u30c1\u30f3\u3092\u670d\u7528\u3067\u304d\u306a\u3044\u5834\u5408\u3001\u304b\u3064\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u307e\u305f\u306f\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u306e\u65b9\u304c\u3001\u30ec\u30d1\u30fc\u30b5\u307e\u305f\u306f\u30ec\u30af\u30d3\u30aa\u306e\u4f7f\u7528\u5bfe\u8c61\u3068\u306a\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u4e21\u5264\u3068\u3082\u30b9\u30bf\u30c1\u30f3\u306b\u3088\u308b\u6cbb\u7642\u304c\u9069\u3055\u306a\u3044\u5834\u5408\u3092\u9664\u304d\u3001\u30b9\u30bf\u30c1\u30f3\u3068\u4f75\u7528\u3059\u308b\u3053\u3068\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3000<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\u30ec\u30d1\u30fc\u30b5\u3068\u30ec\u30af\u30d3\u30aa\u306f\u3001\u7279\u306b\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u306e\u60a3\u8005\u3055\u3093\u306b\u3068\u3063\u3066\u6709\u52b9\u306a\u6cbb\u7642\u9078\u629e\u80a2\u3068\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u75be\u60a3\u306f\u907a\u4f1d\u7684\u306a\u8981\u56e0\u306b\u3088\u308a\u3001\u82e5\u3044\u9803\u304b\u3089LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u9ad8\u304f\u306a\u308a\u3001\u52d5\u8108\u786c\u5316\u304c\u9032\u884c\u3057\u307e\u3059\u3002\u7279\u306b\u51a0\u52d5\u8108\uff08\u5fc3\u81d3\u306b\u6804\u990a\u3092\u4e0e\u3048\u308b\u8840\u7ba1\uff09\u306e\u52d5\u8108\u786c\u5316\u304c\u9032\u307f\u3084\u3059\u304f\u3001\u82e5\u5e74\u6027\u306e\u5fc3\u7b4b\u6897\u585e\u3084\u72ed\u5fc3\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3057\u3084\u304f\u306a\u308a\u307e\u3059\u3002LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u3092\u5c11\u306a\u304f\u3068\u3082100 mg\/dL\u672a\u6e80\u306b\u6291\u3048\u308b\u5fc5\u8981\u304c\u3042\u308b\u3053\u306e\u75be\u60a3\u306b\u304a\u3044\u3066\u3001\u5185\u670d\u85ac\u3060\u3051\u3067\u306f\u76ee\u6a19\u9054\u6210\u304c\u96e3\u3057\u3044\u5834\u5408\u304c\u3042\u308a\u3001\u305d\u306e\u969b\u306b\u306f\u30ec\u30d1\u30fc\u30b5\u307e\u305f\u306f\u30ec\u30af\u30d3\u30aa\u306e\u8ffd\u52a0\u304c\u691c\u8a0e\u3055\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3000<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\u3053\u308c\u30892\u3064\u306e\u85ac\u5264\u306e\u6709\u52b9\u6027\u3092\u6bd4\u8f03\u3059\u308b\u3068\u3001\u4e0b\u56f3\u306b\u793a\u3059\u30ec\u30d1\u30fc\u30b5\u304b\u3089\u30ec\u30af\u30d3\u30aa\u306b\u5207\u308a\u66ff\u3048\u3092\u884c\u3063\u305f\u81e8\u5e8a\u7814\u7a76\uff08ORION-3\u8a66\u9a13\uff09\u306e\u7d50\u679c\u304b\u3089\u3082\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4f4e\u4e0b\u4f5c\u7528\u306b\u3064\u3044\u3066\u660e\u3089\u304b\u306a\u5dee\u306f\u306a\u3044\u3068\u8003\u3048\u307e\u3059\u3002(<a href=\"https:\/\/www.thelancet.com\/journals\/landia\/article\/PIIS2213-8587(22)00353-9\/fulltext\">https:\/\/www.thelancet.com\/journals\/landia\/article\/PIIS2213-8587(22)00353-9\/fulltext<\/a>)<\/p>\n\n\n\n<p>\u3000<\/p>\n\n\n\n<p><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"329\" src=\"https:\/\/nakano-dm.clinic\/blog\/wp-content\/uploads\/2023\/12\/gr2-800x329.jpg\" alt=\"\" class=\"wp-image-160\" style=\"width:420px;height:auto\" srcset=\"https:\/\/nakano-dm.clinic\/blog\/wp-content\/uploads\/2023\/12\/gr2-800x329.jpg 800w, https:\/\/nakano-dm.clinic\/blog\/wp-content\/uploads\/2023\/12\/gr2-400x165.jpg 400w, https:\/\/nakano-dm.clinic\/blog\/wp-content\/uploads\/2023\/12\/gr2.jpg 1135w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"has-text-align-right\">(\u51fa\u5178\uff1aLancet Diabetes Endocrinol. 2023; 11: 109-119)<\/p>\n\n\n\n<p>\u3000<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\u307e\u305f\u3001\u5b89\u5168\u6027\u306b\u3064\u3044\u3066\u3082\u3053\u306e2\u5264\u306b\u306f\u660e\u3089\u304b\u306a\u5dee\u304c\u306a\u3044\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3000<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\u305f\u3060\u3057\u3001\u3053\u306e2\u5264\u306b\u306f\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306b\u95a2\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u5dee\u304c\u3042\u308a\u307e\u3059\u3002\u30ec\u30d1\u30fc\u30b5\u306f\u5927\u898f\u6a21\u81e8\u5e8a\u8a66\u9a13\u3067\u3042\u308bFOURIER\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u3092\u7d0415%\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u3001\u533b\u5b66\u754c\u3067\u6700\u3082\u5f71\u97ff\u529b\u304c\u3042\u308b\u533b\u5b66\u96d1\u8a8c\u3067\u3042\u308bThe New England Journal of Medicine\u306b\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u30ec\u30af\u30d3\u30aa\u306b\u95a2\u3057\u3066\u306f\u307e\u3060\u305d\u306e\u3088\u3046\u306a\u52b9\u679c\u306b\u3064\u3044\u3066\u306e\u5831\u544a\u306f\u3042\u308a\u307e\u305b\u3093\u3002(<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28304224\">https:\/\/pubmed.ncbi.nlm.nih.gov\/28304224<\/a>)<\/p>\n\n\n\n<p>\u3000<\/p>\n\n\n\n<p><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"489\" height=\"351\" src=\"https:\/\/nakano-dm.clinic\/blog\/wp-content\/uploads\/2023\/12\/nejmoa1615664_f2.jpeg\" alt=\"\" class=\"wp-image-161\" style=\"width:322px;height:auto\" srcset=\"https:\/\/nakano-dm.clinic\/blog\/wp-content\/uploads\/2023\/12\/nejmoa1615664_f2.jpeg 489w, https:\/\/nakano-dm.clinic\/blog\/wp-content\/uploads\/2023\/12\/nejmoa1615664_f2-400x287.jpeg 400w\" sizes=\"auto, (max-width: 489px) 100vw, 489px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"has-text-align-right\">(\u51fa\u5178\uff1aN Engl J Med. 2017; 376: 1713-1722)<\/p>\n\n\n\n<p>\u3000<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\u305d\u306e\u305f\u3081\u3001\u73fe\u6642\u70b9\u3067\u306f2\u5264\u3092\u6bd4\u8f03\u3059\u308b\u3068\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306b\u95a2\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u3042\u308b\u30ec\u30d1\u30fc\u30b5\u306e\u65b9\u304c\u6709\u5229\u3068\u8003\u3048\u307e\u3059\u304c\u3001\u30ec\u30d1\u30fc\u30b5\u306f2\u9031\u9593\u3082\u3057\u304f\u306f4\u9031\u9593\u306b1\u56de\u3001\u60a3\u8005\u3055\u3093\u81ea\u8eab\u304c\u76ae\u4e0b\u6ce8\u5c04\u3092\u884c\u3046\u5fc5\u8981\u304c\u3042\u308a\u3001\u3084\u3084\u4f7f\u7528\u3057\u3065\u3089\u3044\u9762\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3000<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\u305d\u308c\u306b\u5bfe\u3057\u3066\u3001\u30ec\u30af\u30d3\u30aa\u306f\u60a3\u8005\u3055\u3093\u304c\u81ea\u5206\u3067\u6295\u4e0e\u3059\u308b\u3053\u3068\u306f\u306a\u304f\u3001\u533b\u7642\u6a5f\u95a2\u3067\u306e\u6295\u4e0e\u304c\u5fc5\u8981\u3067\u3059\u3002\u307e\u305f\u30011\u56de\u76ee\u30682\u56de\u76ee\u306e\u63a5\u7a2e\u3092\u9664\u3051\u3070\u534a\u5e74\u306b1\u56de\u306e\u6295\u4e0e\u3067\u6e08\u3080\u305f\u3081\u3001\u670d\u85ac\u30a2\u30c9\u30d2\u30a2\u30e9\u30f3\u30b9\uff08\u670d\u85ac\u30b3\u30f3\u30d7\u30e9\u30a4\u30a2\u30f3\u30b9\uff09\u306e\u9762\u3067\u512a\u308c\u3066\u3044\u307e\u3059\u3002\u6ce8\u5c04\u624b\u6280\u306b\u81ea\u4fe1\u304c\u306a\u3044\u65b9\u3084\u3001\u85ac\u306e\u6295\u4e0e\u3092\u5fd8\u308c\u3084\u3059\u3044\u65b9\u306b\u3068\u3063\u3066\u306f\u3001\u7279\u306b\u30ec\u30af\u30d3\u30aa\u306e\u4f7f\u7528\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3000<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\u305f\u3060\u3057\u3001\u30ec\u30af\u30d3\u30aa\u306f\u9ad8\u984d\u306a\u6cbb\u7642\u85ac\u3067\u3042\u308b\u30ec\u30d1\u30fc\u30b5\u3068\u6bd4\u8f03\u3057\u3066\u3082\u85ac\u4fa1\u304c\u3055\u3089\u306b\u9ad8\u304f\u30013\u5272\u8ca0\u62c5\u306e\u60a3\u8005\u3055\u3093\u3067\u3042\u308c\u3070\u5e74\u9593\u306e\u85ac\u4fa1\u306f\u7d0426\u4e076\u5343\u5186\u306b\u306a\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u30ec\u30af\u30d3\u30aa\u3092\u4f7f\u7528\u3055\u308c\u308b\u65b9\u306e\u591a\u304f\u304c\u9ad8\u984d\u7642\u990a\u8cbb\u5236\u5ea6\u306e\u5bfe\u8c61\u3068\u306a\u308a\u307e\u3059\u3002\u6cbb\u7642\u8cbb\u306e\u4e00\u90e8\u304c\u8fd4\u9084\u3055\u308c\u308b\u3082\u306e\u306e\u3001\u30ec\u30d1\u30fc\u30b5\u306b\u6bd4\u3079\u308b\u3068\u5272\u9ad8\u3067\u3042\u308b\u3053\u3068\u306f\u907f\u3051\u3089\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u3000<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\u4ee5\u4e0a\u306e\u3053\u3068\u304b\u3089\u3001\u30ec\u30af\u30d3\u30aa\u306e\u4f7f\u7528\u306f\u4f55\u3089\u304b\u306e\u7406\u7531\u3067\u30ec\u30d1\u30fc\u30b5\u3092\u4f7f\u7528\u3067\u304d\u306a\u3044\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u306e\u65b9\u3084\u3001\u865a\u8840\u6027\u5fc3\u75be\u60a3\u5f8c\u306e\u9ad8LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u306e\u65b9\u306a\u3069\u306b\u9650\u3089\u308c\u308b\u3068\u8003\u3048\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3000<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\u305d\u306e\u305f\u3081\u3001\u5f53\u30af\u30ea\u30cb\u30c3\u30af\u3067\u30ec\u30af\u30d3\u30aa\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u306f\u305d\u308c\u307b\u3069\u983b\u7e41\u3067\u306f\u306a\u3044\u3068\u898b\u3066\u3044\u307e\u3059\u304c\u3001\u3082\u3057\u3082\u30ec\u30d1\u30fc\u30b5\u3088\u308a\u3082\u30ec\u30af\u30d3\u30aa\u306e\u4f7f\u7528\u304c\u9069\u3057\u3066\u3044\u308b\u3068\u5224\u65ad\u3055\u308c\u308b\u5834\u5408\u3001\u305d\u306e\u5fc5\u8981\u6027\u3092\u4e01\u5be7\u306b\u3054\u8aac\u660e\u3057\u305f\u4e0a\u3067\u5c0e\u5165\u3057\u305f\u3044\u3068\u8003\u3048\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3000<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\u307e\u305f\u3001\u4eca\u5f8c\u30ec\u30af\u30d3\u30aa\u304c\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u7acb\u8a3c\u3055\u308c\u3001\u85ac\u4fa1\u3082\u30ec\u30d1\u30fc\u30b5\u3068\u540c\u7b49\u306b\u306a\u308c\u3070\u3001\u5f53\u30af\u30ea\u30cb\u30c3\u30af\u3067\u3082\u7a4d\u6975\u7684\u306b\u4f7f\u7528\u3057\u3088\u3046\u3068\u8003\u3048\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3000<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\u52a0\u3048\u3066\u3001\u8102\u8cea\u7570\u5e38\u75c7\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\u306f\u98df\u4e8b\u7642\u6cd5\u304c\u975e\u5e38\u306b\u91cd\u8981\u3067\u3059\u3002\u5f53\u30af\u30ea\u30cb\u30c3\u30af\u3067\u306f\u3001\u5916\u6765\u3067\u5c02\u9580\u306e\u533b\u5e2b\u304c\u98df\u4e8b\u7642\u6cd5\u306b\u3064\u3044\u3066\u5206\u304b\u308a\u3084\u3059\u304f\u3054\u8aac\u660e\u3044\u305f\u3057\u307e\u3059\u3002\u307e\u305f\u7ba1\u7406\u6804\u990a\u58eb\u306b\u3088\u308b\u6804\u990a\u6307\u5c0e\u3082\u884c\u3063\u3066\u304a\u308a\u307e\u3059\u306e\u3067\u3001\u305c\u3072\u3054\u5229\u7528\u306b\u306a\u3063\u3066\u307f\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e2d\u91ce\u99c5\u524d\u5185\u79d1\u30af\u30ea\u30cb\u30c3\u30af 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