{"id":380,"date":"2024-09-13T01:00:00","date_gmt":"2024-09-12T16:00:00","guid":{"rendered":"https:\/\/nakano-dm.clinic\/blog\/?p=380"},"modified":"2024-09-09T22:52:40","modified_gmt":"2024-09-09T13:52:40","slug":"post-380","status":"publish","type":"post","link":"https:\/\/nakano-dm.clinic\/blog\/post-380\/","title":{"rendered":"GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3092\u8d85\u3048\u308b\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u4e88\u5f8c\u6539\u5584\u52b9\u679c\u306b\u3064\u3044\u3066"},"content":{"rendered":"\n

\u6771\u4eac\u306eJR\u4e2d\u91ce\u99c5\u5357\u53e3\u304b\u3089\u3059\u3050\u306e\u3068\u3053\u308d\u3067\u958b\u696d\u3057\u3066\u3044\u308b\u7cd6\u5c3f\u75c5\u5c02\u9580\u533b\u306e\u5927\u5ead\u5065\u53f2\u3067\u3059\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u5f53\u30af\u30ea\u30cb\u30c3\u30af\u3067\u306f\u3001\u80a5\u6e80\u3092\u4f34\u3046\u7cd6\u5c3f\u75c5\u60a3\u8005\u3055\u3093\u304b\u3089\u306e\u3054\u76f8\u8ac7\u304c\u5897\u3048\u3066\u304a\u308a\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3084GIP\/GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u300c\u30de\u30f3\u30b8\u30e3\u30ed\u300d\u306e\u4f7f\u7528\u304c\u5897\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n

(\u51fa\u5178\uff1a\u7530\u8fba\u4e09\u83f1\u88fd\u85ac\u30db\u30fc\u30e0\u30da\u30fc\u30b8)<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n\n

GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306f\u3001\u81b5\u81d3\u306e\u03b2\u7d30\u80de\u3092\u523a\u6fc0\u3057\u3066\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u4fc3\u9032\u3057\u3001\u30b0\u30eb\u30ab\u30b4\u30f3\u5206\u6ccc\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u8840\u7cd6\u5024\u3092\u4f4e\u4e0b\u3055\u305b\u307e\u3059\u3002<\/p>\n\n\n\n

\u307e\u305f\u3001\u80c3\u5185\u5bb9\u7269\u306e\u6392\u51fa\u3092\u9045\u3089\u305b\u3066\u98df\u5f8c\u306e\u8840\u7cd6\u4e0a\u6607\u3092\u6291\u5236\u3057\u3001\u98df\u6b32\u4e2d\u67a2\u306b\u4f5c\u7528\u3057\u3066\u98df\u6b32\u3092\u6291\u3048\u308b\u52b9\u679c\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u3053\u308c\u3089\u306e\u591a\u9762\u7684\u306a\u4f5c\u7528\u306b\u3088\u308a\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306f\u591a\u304f\u306e\u7d4c\u53e3\u8840\u7cd6\u964d\u4e0b\u85ac\u3068\u6bd4\u3079\u3066\u3001\u3088\u308a\u5f37\u529b\u306a\u8840\u7cd6\u964d\u4e0b\u4f5c\u7528\u3068\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u3092\u793a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\u307e\u305f\u3001\u5fc3\u81d3\u3084\u814e\u81d3\u3078\u306e\u4fdd\u8b77\u4f5c\u7528\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u751f\u547d\u4e88\u5f8c\u306e\u6539\u5584\u306b\u3082\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u4e00\u65b9\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u4ee5\u524d\u30d6\u30ed\u30b0\u300cGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u52b9\u679c\u3092\u8d85\u3048\u308b\u30de\u30f3\u30b8\u30e3\u30ed\u3068\u3044\u3046\u85ac\u5264\u306b\u3064\u3044\u3066<\/a>\u300d\u3067\u3082\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3057\u305f\u304c\u3001\u5929\u7136\u306eGIP\uff08\u30b0\u30eb\u30b3\u30fc\u30b9\u4f9d\u5b58\u6027\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u523a\u6fc0\u30dd\u30ea\u30da\u30d7\u30c1\u30c9\uff09\u3092\u30d9\u30fc\u30b9\u306b\u4f5c\u3089\u308c\u3066\u304a\u308a\u3001GIP\u53d7\u5bb9\u4f53\u3060\u3051\u3067\u306a\u304fGLP-1\u53d7\u5bb9\u4f53\u306b\u3082\u4f5c\u7528\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u3053\u306e\u85ac\u5264\u306f\u3001\u7b2c2\u76f8\u81e8\u5e8a\u8a66\u9a13\u3067\u6700\u5927\u7528\u91cf15 mg\u3092\u4f7f\u7528\u3057\u305f\u5834\u5408\u3001\u7d04\u534a\u5e74\u3067\u5e73\u574711.3 kg\u306e\u4f53\u91cd\u6e1b\u5c11\u304c\u898b\u3089\u308c\u3001\u65e2\u5b58\u306eGLP-1\u88fd\u5264\u3067\u3042\u308b\u30c8\u30eb\u30ea\u30b7\u30c6\u30a3\u3092\u5927\u5e45\u306b\u4e0a\u56de\u308b\u52b9\u679c\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002 (https:\/\/pubmed.ncbi.nlm.nih.gov\/30293770<\/a>)<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n

(\u51fa\u5178\uff1aLancet. 2018 17; 392: 2180-2193)<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u305f\u3060\u3057\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u6bd4\u8f03\u7684\u65b0\u3057\u3044\u85ac\u5264\u3067\u3042\u308b\u305f\u3081\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u3088\u3046\u306b\u751f\u547d\u4e88\u5f8c\u3092\u6539\u5584\u3055\u305b\u308b\u3068\u3044\u3046\u660e\u78ba\u306a\u5831\u544a\u306f\u3053\u308c\u307e\u3067\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u3057\u304b\u3057\u30012024\u5e748\u670812\u65e5\u3001\u7c73\u56fd\u533b\u5e2b\u4f1a\u96d1\u8a8c\u300cJAMA Network Open\u300d\u306b\u304a\u3044\u3066\u300cClinical Outcomes of Tirzepatide or GLP-1 Receptor Agonists in Individuals With Type 2 Diabetes\u300d\u3068\u3044\u3046\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u3068\u65e2\u5b58\u306eGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3092\u6bd4\u8f03\u3057\u305f\u7814\u7a76\u7d50\u679c\u304c\u516c\u8868\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u3053\u306e\u8ad6\u6587\u3067\u306f\u3001\u3069\u3061\u3089\u306e\u85ac\u5264\u304c\u3088\u308a\u751f\u547d\u4e88\u5f8c\u3092\u6539\u5584\u3059\u308b\u304b\u306a\u3069\u306b\u3064\u3044\u3066\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3053\u306e\u7814\u7a76\u6210\u679c\u306f\u3001\u4eca\u5f8c\u306e\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u975e\u5e38\u306b\u91cd\u8981\u306a\u3082\u306e\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u305d\u3053\u3067\u4eca\u56de\u306f\u3001\u3053\u306e\u8ad6\u6587\u306e\u8a73\u7d30\u3092\u89e3\u8aac\u3057\u3001\u5f53\u30af\u30ea\u30cb\u30c3\u30af\u3067\u306e\u4eca\u5f8c\u306e\u6cbb\u7642\u65b9\u91dd\u306b\u3064\u3044\u3066\u3082\u304a\u8a71\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3059\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u30de\u30f3\u30b8\u30e3\u30ed\u3068\u65e2\u5b58\u306eGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3092\u6bd4\u8f03\u3057\u305f\u7814\u7a76\u7d50\u679c\u306b\u3064\u3044\u3066<\/strong><\/h2>\n\n\n\n

\u3053\u306e\u7814\u7a76\u306f\u30012022\u5e746\u67081\u65e5\u304b\u30892023\u5e746\u670830\u65e5\u306e\u9593\u306b\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u307e\u305f\u306fGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3092\u958b\u59cb\u3057\u305f\u30a2\u30e1\u30ea\u30ab\u306e2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005140,308\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u4e21\u85ac\u5264\u3092\u4f7f\u7528\u3057\u305f\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u5168\u6b7b\u4ea1\u7387\u3001\u4e3b\u8981\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08MACE: Major Adverse Cardiovascular Events\uff09\u3001\u814e\u30a4\u30d9\u30f3\u30c8\uff08\u814e\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3084\u900f\u6790\u5c0e\u5165\u306a\u3069\uff09\u3001\u6025\u6027\u814e\u969c\u5bb3\u306e\u30ea\u30b9\u30af\u3092\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u305d\u306e\u7d50\u679c\u3001\u4e0b\u56f3\u306b\u793a\u3059\u901a\u308a\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u5168\u6b7b\u4ea1\u7387\u3092\u7d0442%\u3001\u4e3b\u8981\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u7d0420%\u3001\u814e\u30a4\u30d9\u30f3\u30c8\u3092\u7d0448%\u3001\u6025\u6027\u814e\u969c\u5bb3\u3092\u7d0422%\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n

\n
\"\"<\/figure>\n<\/div>\n\n\n

(\u51fa\u5178\uff1aJAMA Netw Open.\u00a02024 1; 7: e2427258) <\/p>\n\n\n\n

<\/p>\n\n\n\n

\u3053\u306e\u7d50\u679c\u304b\u3089\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u4f53\u91cd\u3084\u8840\u7cd6\u306e\u6539\u5584\u3060\u3051\u3067\u306a\u304f\u3001\u5fc3\u8840\u7ba1\u304a\u3088\u3073\u814e\u30a4\u30d9\u30f3\u30c8\u3001\u751f\u547d\u4e88\u5f8c\u306b\u304a\u3044\u3066\u3082\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u52b9\u679c\u3092\u4e0a\u56de\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u30de\u30f3\u30b8\u30e3\u30ed\u306f\u6700\u5584\u306e\u6cbb\u7642\u85ac\u306a\u306e\u304b\uff1f<\/strong><\/h2>\n\n\n\n

\u305d\u308c\u3067\u306f\u3001\u5fc3\u814e\u30a4\u30d9\u30f3\u30c8\u3084\u751f\u547d\u4e88\u5f8c\u306e\u6539\u5584\u304c\u671f\u5f85\u3055\u308c\u308b\u30de\u30f3\u30b8\u30e3\u30ed\u304c\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3092\u4e0a\u56de\u308b\u6700\u5584\u306e\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u304b\u3068\u3044\u3046\u3068\u3001\u79c1\u306f\u305d\u3046\u3068\u306f\u8a00\u3044\u5207\u308c\u306a\u3044\u3068\u8003\u3048\u307e\u3059\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n\n

GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u4e2d\u3067\u3082\u3001\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u304c\u6700\u3082\u9ad8\u3044\u30aa\u30bc\u30f3\u30d4\u30c3\u30af\u3084\u30a6\u30b4\u30fc\u30d3\u306b\u3064\u3044\u3066\u306f\u3001\u73fe\u6642\u70b9\u3067\u30de\u30f3\u30b8\u30e3\u30ed\u3068\u306e\u76f4\u63a5\u6bd4\u8f03\u7814\u7a76\u304c\u306a\u3044\u305f\u3081\u3001\u512a\u52a3\u3092\u6c7a\u3081\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u3055\u3089\u306b\u3001\u4f53\u91cd\u6e1b\u5c11\u52b9\u679c\u304c\u6bd4\u8f03\u7684\u5f31\u3044\u30d3\u30af\u30c8\u30fc\u30b6\u3084\u30c8\u30eb\u30ea\u30b7\u30c6\u30a3\u306b\u304a\u3044\u3066\u3082\u3001\u305d\u308c\u305e\u308c\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u6e1b\u5c11\u3055\u305b\u308b\u52b9\u679c\u304c\u78ba\u8a8d\u3055\u308c\u3066\u304a\u308a\u3001\u80a5\u6e80\u304c\u306a\u30442\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3055\u3093\u306b\u3068\u3063\u3066\u306f\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u3088\u308a\u3082\u512a\u308c\u305f\u9078\u629e\u80a2\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002(https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1603827#t=article<\/a>)(https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(19)31149-3\/abstract<\/a>) <\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u4ee5\u4e0a\u306e\u70b9\u304b\u3089\u3001\u3053\u306e\u8ad6\u6587\u306b\u3088\u3063\u3066\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u512a\u4f4d\u6027\u304c\u793a\u3055\u308c\u305f\u4e00\u65b9\u3067\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3082\u4f9d\u7136\u3068\u3057\u3066\u512a\u308c\u305f\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u3067\u3042\u308b\u3053\u3068\u306b\u5909\u308f\u308a\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n\n

GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u304b\u3089\u30de\u30f3\u30b8\u30e3\u30ed\u3078\u306e\u5207\u308a\u66ff\u3048\u306b\u3064\u3044\u3066<\/strong><\/h2>\n\n\n\n

\u5f53\u30af\u30ea\u30cb\u30c3\u30af\u3067\u306f\u3001\u73fe\u5728GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3067\u6cbb\u7642\u304c\u5b89\u5b9a\u3057\u3066\u3044\u308b\u65b9\u306b\u5bfe\u3057\u3066\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u3078\u306e\u5207\u308a\u66ff\u3048\u3092\u5f37\u304f\u304a\u52e7\u3081\u3059\u308b\u3053\u3068\u306f\u3042\u307e\u308a\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u3057\u304b\u3057\u3001BMI\u304c35 kg\/m2<\/sup>\u4ee5\u4e0a\u306e\u9ad8\u5ea6\u80a5\u6e80\u304c\u3042\u308b\u65b9\u3084\u3001\u80a5\u6e80\u306b\u95a2\u9023\u3059\u308b\u5065\u5eb7\u969c\u5bb3\uff08\u8102\u8cea\u7570\u5e38\u75c7\u3084\u9ad8\u8840\u5727\u75c7\u306a\u3069\uff09\u3092\u8907\u6570\u62b1\u3048\u3066\u3044\u308b\u65b9\u306b\u306f\u3001\u30aa\u30bc\u30f3\u30d4\u30c3\u30af\u4ee5\u5916\u306eGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3092\u4f7f\u7528\u3057\u3066\u3044\u308b\u5834\u5408\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u3078\u306e\u5207\u308a\u66ff\u3048\u3092\u304a\u52e7\u3081\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u4eca\u5f8c\u306e\u30de\u30f3\u30b8\u30e3\u30ed\u306b\u3064\u3044\u3066<\/strong><\/h2>\n\n\n\n

\u30de\u30f3\u30b8\u30e3\u30ed\u306e\u7cd6\u5c3f\u75c5\u60a3\u8005\u3055\u3093\u3078\u306e\u5fc3\u814e\u30a4\u30d9\u30f3\u30c8\u3084\u751f\u547d\u4e88\u5f8c\u306a\u3069\u3092\u6539\u5584\u3055\u305b\u308b\u52b9\u679c\u306f\u3001\u7cd6\u5c3f\u75c5\u60a3\u8005\u3055\u3093\u4ee5\u5916\u3067\u3082\u8a8d\u3081\u3089\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u3059\u3067\u306b\u30a2\u30e1\u30ea\u30ab\u3067\u306f\u30012023\u5e7412\u6708\u306b\u7cd6\u5c3f\u75c5\u306e\u306a\u3044\u80a5\u6e80\u306e\u65b9\u3092\u5bfe\u8c61\u306b\u3001\u30de\u30f3\u30b8\u30e3\u30ed\u3068\u540c\u3058\u6210\u5206\u3067\u3042\u308b\u30bc\u30c3\u30d7\u30d0\u30a6\u30f3\u30c9\u304c\u767a\u58f2\u3055\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u52b9\u679c\u304c\u7acb\u8a3c\u3055\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u307e\u305f\u3001\u65e5\u672c\u3067\u30822025\u5e74\u9803\u306b\u306f\u3001\u4fdd\u967a\u8a3a\u7642\u3067\u7cd6\u5c3f\u75c5\u306e\u306a\u3044\u65b9\u306b\u3082\u30de\u30f3\u30b8\u30e3\u30ed\u307e\u305f\u306f\u30bc\u30c3\u30d7\u30d0\u30a6\u30f3\u30c9\u304c\u4f7f\u7528\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u3053\u306e\u3088\u3046\u306b\u3001\u9ad8\u984d\u306a\u81ea\u7531\u8a3a\u7642\u3067\u306f\u306a\u304f\u3001\u4fdd\u967a\u8a3a\u7642\u306e\u7bc4\u56f2\u3067\u30de\u30f3\u30b8\u30e3\u30ed\u304c\u5e83\u304f\u4f7f\u7528\u3055\u308c\u308b\u3053\u3068\u3092\u671f\u5f85\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u6700\u5f8c\u306b<\/strong><\/h2>\n\n\n\n

\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u306f\u6bce\u5e74\u306e\u3088\u3046\u306b\u65b0\u305f\u306a\u3082\u306e\u304c\u767a\u58f2\u3055\u308c\u3001\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306f\u6025\u901f\u306b\u9032\u6b69\u3057\u3066\u3044\u307e\u3059\u3002\u5f53\u30af\u30ea\u30cb\u30c3\u30af\u306f\u30013\u540d\u306e\u7cd6\u5c3f\u75c5\u5c02\u9580\u533b\u304c\u5728\u7c4d\u3059\u308b\u7cd6\u5c3f\u75c5\u5c02\u9580\u306e\u30af\u30ea\u30cb\u30c3\u30af\u3067\u3059\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u6700\u65b0\u306e\u533b\u5b66\u8ad6\u6587\u3092\u5e38\u306b\u53c2\u8003\u306b\u3057\u306a\u304c\u3089\u3001\u6700\u5148\u7aef\u306e\u533b\u7642\u3092\u63d0\u4f9b\u3067\u304d\u308b\u3088\u3046\u65e5\u3005\u52aa\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n\n

\u73fe\u5728\u306e\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306b\u4e0d\u5b89\u3084\u7591\u554f\u3092\u304a\u6301\u3061\u306e\u65b9\u306f\u3001\u305c\u3072\u4e00\u5ea6\u5f53\u30af\u30ea\u30cb\u30c3\u30af\u3092\u53d7\u8a3a\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n

\u7cd6\u5c3f\u75c5\u5c02\u9580\u533b\u304c\u3001\u5206\u304b\u308a\u3084\u3059\u304f\u4e01\u5be7\u306b\u3054\u8aac\u660e\u3044\u305f\u3057\u307e\u3059\u3002 <\/p>\n\n\n\n

\u3000<\/p>\n\n\n\n

<\/p>\n\n\n\n

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\n
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