{"id":977,"date":"2026-07-18T12:00:00","date_gmt":"2026-07-18T03:00:00","guid":{"rendered":"https:\/\/nakano-dm.clinic\/blog\/?p=977"},"modified":"2026-07-14T16:27:17","modified_gmt":"2026-07-14T07:27:17","slug":"post-977","status":"publish","type":"post","link":"https:\/\/nakano-dm.clinic\/blog\/post-977\/","title":{"rendered":"2026\u5e746\u6708\u304b\u3089MASH\uff08\u4ee3\u8b1d\u6a5f\u80fd\u969c\u5bb3\u95a2\u9023\u8102\u80aa\u809d\u708e\uff09\u306b\u30a6\u30b4\u30fc\u30d3\u304c\u4f7f\u7528\u53ef\u80fd"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u76ee\u6b21<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"#introduction\">\u306f\u3058\u3081\u306b<\/a><\/li>\n\n\n\n<li><a href=\"#masld-mash\">MASLD\u3068MASH\u3068\u306f\uff1f<\/a><\/li>\n\n\n\n<li><a href=\"#global-approval\">\u4e16\u754c\u3067\u76f8\u6b21\u3050MASH\u6cbb\u7642\u85ac\u306e\u627f\u8a8d<\/a><\/li>\n\n\n\n<li><a href=\"#wegovy-mechanism\">\u30a6\u30b4\u30fc\u30d3\u306f\u3069\u306e\u3088\u3046\u306bMASH\u3092\u6539\u5584\u3059\u308b\u306e\uff1f<\/a><\/li>\n\n\n\n<li><a href=\"#wegovy-dose\">\u6295\u4e0e\u65b9\u6cd5\u306f\u80a5\u6e80\u75c7\u3068\u540c\u3058<\/a><\/li>\n\n\n\n<li><a href=\"#essence-trial\">ESSENCE\u8a66\u9a13\u304c\u793a\u3057\u305fMASH\u6539\u5584\u52b9\u679c<\/a><\/li>\n\n\n\n<li><a href=\"#diagnosis\">MASH\u306f\u8840\u6db2\u691c\u67fb\u3060\u3051\u3067\u306f\u8a3a\u65ad\u3067\u304d\u307e\u305b\u3093<\/a><\/li>\n\n\n\n<li><a href=\"#guideline\">\u6700\u9069\u4f7f\u7528\u63a8\u9032\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306f\u5c02\u9580\u7684\u306a\u7dda\u7dad\u5316\u8a55\u4fa1\u304c\u5fc5\u8981<\/a><\/li>\n\n\n\n<li><a href=\"#fibrosis\">\u306a\u305c\u4e2d\u7b49\u5ea6\uff5e\u9ad8\u5ea6\u306e\u7dda\u7dad\u5316\uff08F2\uff5eF3\uff09\u304c\u5bfe\u8c61\u3067\u3001\u809d\u786c\u5909\uff08F4\uff09\u306f\u5bfe\u8c61\u5916\u306a\u306e\uff1f<\/a><\/li>\n\n\n\n<li><a href=\"#specialist\">\u5c02\u9580\u65bd\u8a2d\u3067\u306e\u8a3a\u7642\u304c\u6c42\u3081\u3089\u308c\u308b\u7406\u7531<\/a><\/li>\n\n\n\n<li><a href=\"#clinic\">\u5f53\u30af\u30ea\u30cb\u30c3\u30af\u3067\u3067\u304d\u308b\u3053\u3068<\/a><\/li>\n\n\n\n<li><a href=\"#future\">\u4eca\u5f8c\u671f\u5f85\u3055\u308c\u308bMASH\u6cbb\u7642<\/a><\/li>\n\n\n\n<li><a href=\"#summary\">\u307e\u3068\u3081<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u306f\u3058\u3081\u306b<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u5065\u5eb7\u8a3a\u65ad\u3067\u300c\u8102\u80aa\u809d\u304c\u3042\u308a\u307e\u3059\u306d\u300d\u3068\u8a00\u308f\u308c\u305f\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u304b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"660\" height=\"600\" src=\"https:\/\/nakano-dm.clinic\/blog\/wp-content\/uploads\/2026\/07\/27242246-660x600.jpg\" alt=\"\" class=\"wp-image-982\" style=\"width:325px;height:auto\" srcset=\"https:\/\/nakano-dm.clinic\/blog\/wp-content\/uploads\/2026\/07\/27242246-660x600.jpg 660w, https:\/\/nakano-dm.clinic\/blog\/wp-content\/uploads\/2026\/07\/27242246-330x300.jpg 330w, https:\/\/nakano-dm.clinic\/blog\/wp-content\/uploads\/2026\/07\/27242246.jpg 844w\" sizes=\"auto, (max-width: 660px) 100vw, 660px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8102\u80aa\u809d\u306f\u4ee5\u524d\u3001\u300c\u304a\u9152\u3092\u98f2\u307f\u904e\u304e\u308b\u4eba\u306e\u75c5\u6c17\u300d\u3084\u300c\u7279\u306b\u6cbb\u7642\u306e\u5fc5\u8981\u306f\u306a\u3044\u300d\u3068\u8003\u3048\u3089\u308c\u308b\u3053\u3068\u3082\u5c11\u306a\u304f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u304b\u3057\u8fd1\u5e74\u3067\u306f\u3001\u304a\u9152\u3092\u307b\u3068\u3093\u3069\u98f2\u307e\u306a\u3044\u65b9\u3067\u3082\u3001\u80a5\u6e80\u3084\u7cd6\u5c3f\u75c5\u3001\u8102\u8cea\u7570\u5e38\u75c7\u306a\u3069\u306e\u751f\u6d3b\u7fd2\u6163\u75c5\u304c\u539f\u56e0\u3067\u8102\u80aa\u809d\u3092\u767a\u75c7\u3057\u3001\u305d\u306e\u4e00\u90e8\u306f\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u809d\u75be\u60a3\u3068\u540c\u3058\u3088\u3046\u306b\u3001\u809d\u786c\u5909\u3084\u809d\u7d30\u80de\u304c\u3093\u3078\u9032\u884c\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7279\u306b\u3001\u8102\u80aa\u809d\u306b\u708e\u75c7\u3084\u809d\u81d3\u306e\u7dda\u7dad\u5316\uff08\u809d\u81d3\u304c\u786c\u304f\u306a\u308b\u3053\u3068\uff09\u3092\u4f34\u3046MASH\uff08\u4ee3\u8b1d\u6a5f\u80fd\u969c\u5bb3\u95a2\u9023\u8102\u80aa\u809d\u708e\uff1aMetabolic dysfunction-associated steatohepatitis\uff09\u306f\u3001\u9032\u884c\u3059\u308b\u3068\u809d\u786c\u5909\u3084\u809d\u304c\u3093\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u65e9\u671f\u767a\u898b\u3068\u9069\u5207\u306a\u6cbb\u7642\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u3046\u3057\u305f\u4e2d\u30012026\u5e746\u670819\u65e5\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3067\u3042\u308b\u30a6\u30b4\u30fc\u30d3\uff08\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\uff09\u306e\u9069\u5fdc\u304c\u65e5\u672c\u3067\u62e1\u5927\u3055\u308c\u3001\u809d\u786c\u5909\u3092\u4f34\u308f\u306a\u3044MASH\u306b\u5bfe\u3057\u3066\u4fdd\u967a\u8a3a\u7642\u3067\u4f7f\u7528\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"429\" height=\"218\" src=\"https:\/\/nakano-dm.clinic\/blog\/wp-content\/uploads\/2026\/07\/defd7e80f0697249bd24f148e252c98e.png\" alt=\"\" class=\"wp-image-983\" srcset=\"https:\/\/nakano-dm.clinic\/blog\/wp-content\/uploads\/2026\/07\/defd7e80f0697249bd24f148e252c98e.png 429w, https:\/\/nakano-dm.clinic\/blog\/wp-content\/uploads\/2026\/07\/defd7e80f0697249bd24f148e252c98e-400x203.png 400w\" sizes=\"auto, (max-width: 429px) 100vw, 429px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u306f\u3001\u65e5\u672c\u3067\u521d\u3081\u3066MASH\u306b\u5bfe\u3057\u3066\u627f\u8a8d\u3055\u308c\u305f\u85ac\u7269\u7642\u6cd5\u3067\u3042\u308a\u3001\u3053\u308c\u307e\u3067\u98df\u4e8b\u7642\u6cd5\u3084\u904b\u52d5\u7642\u6cd5\u304c\u4e2d\u5fc3\u3060\u3063\u305f\u6cbb\u7642\u306b\u65b0\u305f\u306a\u9078\u629e\u80a2\u304c\u52a0\u308f\u3063\u305f\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3067\u3001\u30a6\u30b4\u30fc\u30d3\u306f\u8102\u80aa\u809d\u3068\u8a3a\u65ad\u3055\u308c\u305f\u3059\u3079\u3066\u306e\u65b9\u304c\u4f7f\u7528\u3067\u304d\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002MASH\u3068\u8a3a\u65ad\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u8102\u80aa\u809d\u304c\u708e\u75c7\u3084\u7dda\u7dad\u5316\u3092\u4f34\u3046\u6bb5\u968e\u307e\u3067\u9032\u884c\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u5c02\u9580\u7684\u306a\u691c\u67fb\u3067\u78ba\u8a8d\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001\u539a\u751f\u52b4\u50cd\u7701\u306f\u6700\u9069\u4f7f\u7528\u63a8\u9032\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3092\u7b56\u5b9a\u3057\u3001\u5bfe\u8c61\u3068\u306a\u308b\u60a3\u8005\u3055\u3093\u3084\u51e6\u65b9\u3067\u304d\u308b\u533b\u7642\u6a5f\u95a2\u3092\u5b9a\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306f\u3001MASH\u3068\u306f\u3069\u306e\u3088\u3046\u306a\u75c5\u6c17\u306a\u306e\u304b\u3001\u30a6\u30b4\u30fc\u30d3\u306b\u3088\u308b\u6cbb\u7642\u306e\u5bfe\u8c61\u3068\u306a\u308b\u60a3\u8005\u3055\u3093\u306f\u3069\u306e\u3088\u3046\u306a\u65b9\u306a\u306e\u304b\u306b\u3064\u3044\u3066\u3001\u6700\u65b0\u306e\u81e8\u5e8a\u8a66\u9a13\u306e\u7d50\u679c\u3084\u56fd\u5185\u5916\u306e\u627f\u8a8d\u72b6\u6cc1\u3082\u4ea4\u3048\u306a\u304c\u3089\u3001\u5206\u304b\u308a\u3084\u3059\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>MASLD\u3068MASH\u3068\u306f\uff1f<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ee5\u524d\u306f\u3001\u8102\u80aa\u809d\u306e\u75c5\u6c17\u306f\u300cNAFLD\uff08\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u6027\u809d\u75be\u60a3\uff09\u300d\u3001\u305d\u306e\u4e2d\u3067\u3082\u708e\u75c7\u3092\u4f34\u3046\u3082\u306e\u306f\u300cNASH\uff08\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u809d\u708e\uff09\u300d\u3068\u547c\u3070\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3057\u304b\u3057\u30012023\u5e74\u306b\u56fd\u969b\u7684\u306a\u5c02\u9580\u5bb6\u306b\u3088\u308b\u691c\u8a0e\u3092\u7d4c\u3066\u3001\u75c5\u540d\u304c\u898b\u76f4\u3055\u308c\u3001\u73fe\u5728\u3067\u306f\u300cMASLD\uff08\u4ee3\u8b1d\u6a5f\u80fd\u969c\u5bb3\u95a2\u9023\u8102\u80aa\u6027\u809d\u75be\u60a3\uff09\u300d\u3068\u300cMASH\uff08\u4ee3\u8b1d\u6a5f\u80fd\u969c\u5bb3\u95a2\u9023\u8102\u80aa\u809d\u708e\uff09\u300d\u3068\u3044\u3046\u540d\u79f0\u304c\u4f7f\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">MASLD\u3068\u306f\u3001\u80a5\u6e80\u3084\u7cd6\u5c3f\u75c5\u3001\u8102\u8cea\u7570\u5e38\u75c7\u306a\u3069\u306e\u751f\u6d3b\u7fd2\u6163\u75c5\u3092\u80cc\u666f\u306b\u3001\u809d\u81d3\u3078\u8102\u80aa\u304c\u904e\u5270\u306b\u84c4\u7a4d\u3057\u305f\u72b6\u614b\u3092\u6307\u3057\u307e\u3059\u3002\u30a2\u30eb\u30b3\u30fc\u30eb\u306e\u98f2\u307f\u904e\u304e\u304c\u539f\u56e0\u3068\u306a\u308b\u8102\u80aa\u809d\u3092\u9664\u304f\u3068\u3001\u8102\u80aa\u809d\u306e\u591a\u304f\u306fMASLD\u306b\u5206\u985e\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3001MASH\u306f\u3001\u8102\u80aa\u304c\u84c4\u7a4d\u3057\u3066\u3044\u308b\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u809d\u81d3\u306b\u708e\u75c7\u3084\u7d30\u80de\u306e\u969c\u5bb3\u304c\u8d77\u3053\u308a\u3001\u3055\u3089\u306b\u7dda\u7dad\u5316\uff08\u809d\u81d3\u304c\u786c\u304f\u306a\u308b\u3053\u3068\uff09\u304c\u9032\u884c\u3057\u3066\u3044\u308b\u72b6\u614b\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">MASH\u3092\u653e\u7f6e\u3059\u308b\u3068\u3001\u7dda\u7dad\u5316\u304c\u3055\u3089\u306b\u9032\u3093\u3067\u809d\u786c\u5909\u3068\u306a\u308a\u3001\u809d\u4e0d\u5168\u3084\u809d\u7d30\u80de\u304c\u3093\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"600\" src=\"https:\/\/nakano-dm.clinic\/blog\/wp-content\/uploads\/2026\/07\/23543321-1-800x600.jpg\" alt=\"\" class=\"wp-image-985\" style=\"width:478px;height:auto\" srcset=\"https:\/\/nakano-dm.clinic\/blog\/wp-content\/uploads\/2026\/07\/23543321-1-800x600.jpg 800w, https:\/\/nakano-dm.clinic\/blog\/wp-content\/uploads\/2026\/07\/23543321-1-400x300.jpg 400w, https:\/\/nakano-dm.clinic\/blog\/wp-content\/uploads\/2026\/07\/23543321-1.jpg 1600w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001MASH\u306f\u809d\u81d3\u3060\u3051\u306e\u75c5\u6c17\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u7cd6\u5c3f\u75c5\u3084\u80a5\u6e80\u3001\u8102\u8cea\u7570\u5e38\u75c7\u306a\u3069\u3092\u4f34\u3046\u3053\u3068\u304c\u591a\u304f\u3001\u5fc3\u7b4b\u6897\u585e\u3084\u8133\u6897\u585e\u306a\u3069\u306e\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3082\u9ad8\u307e\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u73fe\u5728\u3001\u65e5\u672c\u3067\u306f\u7d042,500\u4e07\u4eba\u304cMASLD\u3067\u3042\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3001\u305d\u306e\u3046\u3061\u6570\u767e\u4e07\u4eba\u304cMASH\u3078\u9032\u884c\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7279\u306b\u7cd6\u5c3f\u75c5\u306e\u3042\u308b\u65b9\u3067\u306fMASH\u3092\u5408\u4f75\u3057\u3084\u3059\u304f\u30012\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3055\u3093\u306e\u7d043\u4eba\u306b1\u4eba\uff0831.6\uff05\uff09\u304cMASH\u3092\u5408\u4f75\u3057\u3066\u3044\u308b\u3068\u306e\u5831\u544a\u3082\u3042\u308a\u307e\u3059\u3002(<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37491159\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/pubmed.ncbi.nlm.nih.gov\/37491159<\/a>)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u4e16\u754c\u3067\u76f8\u6b21\u3050MASH\u6cbb\u7642\u85ac\u306e\u627f\u8a8d<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">MASH\u306b\u5bfe\u3059\u308b\u85ac\u306e\u958b\u767a\u306f20\u5e74\u4ee5\u4e0a\u524d\u304b\u3089\u9032\u3081\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u3053\u308c\u307e\u3067\u5341\u5206\u306a\u52b9\u679c\u3092\u793a\u3057\u3001\u627f\u8a8d\u307e\u3067\u81f3\u3063\u305f\u6cbb\u7642\u85ac\u306f\u591a\u304f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u3088\u3046\u306a\u4e2d\u30012024\u5e743\u6708\u3001\u7c73\u56fd\u98df\u54c1\u533b\u85ac\u54c1\u5c40\uff08FDA\uff09\u306f\u3001\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u03b2\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3067\u3042\u308b\u30ec\u30ba\u30e1\u30c1\u30ed\u30e0\uff08resmetirom\uff09\u3092\u3001\u4e2d\u7b49\u5ea6\u304b\u3089\u9ad8\u5ea6\u306e\u809d\u7dda\u7dad\u5316\uff08F2\uff5eF3\uff09\u3092\u4f34\u3046MASH\u306b\u5bfe\u3059\u308b\u4e16\u754c\u521d\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u627f\u8a8d\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306b2025\u5e748\u6708\u306b\u306f\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3067\u3042\u308b\u30a6\u30b4\u30fc\u30d3\u304cFDA\u3067MASH\u3078\u306e\u9069\u5fdc\u8ffd\u52a0\u627f\u8a8d\u3092\u53d6\u5f97\u3057\u3001\u305d\u306e\u5f8c\u6b27\u5dde\u3067\u3082\u627f\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u65e5\u672c\u3067\u3082\u7d041\u5e74\u5f8c\u306e2026\u5e746\u670819\u65e5\u306b\u9069\u5fdc\u304c\u8ffd\u52a0\u3055\u308c\u3001\u809d\u786c\u5909\u3092\u4f34\u308f\u306a\u3044MASH\u306b\u5bfe\u3057\u3066\u4fdd\u967a\u8a3a\u7642\u3067\u4f7f\u7528\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u65e5\u672c\u3067\u30a6\u30b4\u30fc\u30d3\u304cMASH\u306b\u4fdd\u967a\u9069\u7528\u3068\u306a\u3063\u305f\u3053\u3068\u306f\u3001\u3053\u308c\u307e\u3067\u98df\u4e8b\u7642\u6cd5\u3084\u904b\u52d5\u7642\u6cd5\u304c\u4e2d\u5fc3\u3060\u3063\u305fMASH\u6cbb\u7642\u306b\u65b0\u305f\u306a\u9078\u629e\u80a2\u304c\u52a0\u308f\u3063\u305f\u3053\u3068\u3092\u610f\u5473\u3057\u3001\u7cd6\u5c3f\u75c5\u8a3a\u7642\u3060\u3051\u3067\u306a\u304f\u809d\u81d3\u75c5\u8a3a\u7642\u306b\u304a\u3044\u3066\u3082\u5927\u304d\u306a\u8ee2\u63db\u70b9\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u30a6\u30b4\u30fc\u30d3\u306f\u3069\u306e\u3088\u3046\u306bMASH\u3092\u6539\u5584\u3059\u308b\u306e\uff1f<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u30a6\u30b4\u30fc\u30d3\u306f\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306b\u5206\u985e\u3055\u308c\u308b\u90311\u56de\u306e\u76ae\u4e0b\u6ce8\u5c04\u85ac\u3067\u3059\u3002GLP-1\u306f\u98df\u4e8b\u3092\u3059\u308b\u3068\u5c0f\u8178\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u30db\u30eb\u30e2\u30f3\u3067\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u5206\u6ccc\u3092\u4fc3\u3057\u3001\u98df\u6b32\u3092\u6291\u3048\u308b\u50cd\u304d\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30a6\u30b4\u30fc\u30d3\u306b\u306f\u3001\u6b21\u306e\u3088\u3046\u306a\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fb\u98df\u6b32\u3092\u6291\u3048\u3066\u98df\u3079\u904e\u304e\u3092\u9632\u3050<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fb\u80c3\u304b\u3089\u98df\u3079\u7269\u304c\u9001\u308a\u51fa\u3055\u308c\u308b\u901f\u5ea6\u3092\u3086\u3063\u304f\u308a\u306b\u3057\u3001\u6e80\u8179\u611f\u3092\u6301\u7d9a\u3055\u305b\u308b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fb\u4f53\u91cd\u3092\u6e1b\u5c11\u3055\u305b\u308b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fb\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u52b9\u304d\u3092\u6539\u5584\u3059\u308b\uff08\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306e\u6539\u5584\uff09<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30fb\u5185\u81d3\u8102\u80aa\u3084\u809d\u81d3\u306b\u305f\u307e\u3063\u305f\u8102\u80aa\u3092\u6e1b\u3089\u3059<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">MASH\u306f\u3001\u80a5\u6e80\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u6df1\u304f\u95a2\u308f\u308b\u75c5\u6c17\u3067\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u30a6\u30b4\u30fc\u30d3\u306f\u4f53\u91cd\u3092\u6e1b\u3089\u3059\u3060\u3051\u3067\u306a\u304f\u3001\u809d\u81d3\u3084\u8102\u80aa\u7d44\u7e54\u306e\u6162\u6027\u7684\u306a\u708e\u75c7\u3092\u6539\u5584\u3057\u3001\u809d\u7d30\u80de\u3078\u306e\u30c0\u30e1\u30fc\u30b8\u3084\u809d\u7dda\u7dad\u5316\uff08\u809d\u81d3\u304c\u786c\u304f\u306a\u308b\u3053\u3068\uff09\u306e\u9032\u884c\u3092\u6291\u3048\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u6295\u4e0e\u65b9\u6cd5\u306f\u80a5\u6e80\u75c7\u3068\u540c\u3058<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">MASH\u306b\u5bfe\u3059\u308b\u30a6\u30b4\u30fc\u30d3\u306e\u6295\u4e0e\u65b9\u6cd5\u306f\u3001\u80a5\u6e80\u75c7\u3067\u4f7f\u7528\u3059\u308b\u5834\u5408\u3068\u540c\u3058\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305a\u306f\u90311\u56de\u30010.25 mg\u304b\u3089\u76ae\u4e0b\u6ce8\u5c04\u3092\u958b\u59cb\u3057\u307e\u3059\u3002\u305d\u306e\u5f8c\u3001\u526f\u4f5c\u7528\u3092\u3067\u304d\u308b\u3060\u3051\u5c11\u306a\u304f\u3059\u308b\u305f\u3081\u30014\u9031\u9593\u3054\u3068\u306b0.5 mg\u30011.0 mg\u30011.7 mg\u3068\u5c11\u3057\u305a\u3064\u5897\u91cf\u3057\u3001\u6700\u7d42\u7684\u306b2.4 mg\u3092\u7dad\u6301\u91cf\u3068\u3057\u3066\u6cbb\u7642\u3092\u7d9a\u3051\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6025\u306b\u85ac\u306e\u91cf\u3092\u5897\u3084\u3059\u3068\u3001\u5410\u304d\u6c17\u3001\u5614\u5410\u3001\u98df\u6b32\u4e0d\u632f\u3001\u4fbf\u79d8\u3084\u4e0b\u75e2\u306a\u3069\u306e\u6d88\u5316\u5668\u75c7\u72b6\u304c\u8d77\u3053\u308a\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u4f53\u3092\u85ac\u306b\u6163\u3089\u3057\u306a\u304c\u3089\u3001\u6642\u9593\u3092\u304b\u3051\u3066\u6bb5\u968e\u7684\u306b\u5897\u91cf\u3057\u3066\u3044\u304f\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>ESSENCE\u8a66\u9a13\u304c\u793a\u3057\u305fMASH\u6539\u5584\u52b9\u679c<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u56de\u306e\u627f\u8a8d\u306e\u6839\u62e0\u3068\u306a\u3063\u305f\u306e\u304c\u3001ESSENCE\u8a66\u9a13\u3068\u547c\u3070\u308c\u308b\u56fd\u969b\u5171\u540c\u7b2c\u2162\u76f8\u8a66\u9a13\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u8a66\u9a13\u3067\u306f\u3001\u4e2d\u7b49\u5ea6\u304b\u3089\u9ad8\u5ea6\u306e\u809d\u7dda\u7dad\u5316\uff08F2\uff5eF3\uff09\u3092\u4f34\u3046MASH\u60a3\u8005\u3055\u3093\u7d04800\u4eba\u3092\u5bfe\u8c61\u306b\u3001\u30a6\u30b4\u30fc\u30d32.4 mg\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\uff08\u6709\u52b9\u6210\u5206\u3092\u542b\u307e\u306a\u3044\u85ac\uff09\u3092\u90311\u56de\u300172\u9031\u9593\u6295\u4e0e\u3057\u3001\u305d\u306e\u52b9\u679c\u3068\u5b89\u5168\u6027\u304c\u6bd4\u8f03\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u7d50\u679c\u3001\u809d\u7dda\u7dad\u5316\u3092\u60aa\u5316\u3055\u305b\u308b\u3053\u3068\u306a\u304fMASH\u304c\u6539\u5584\u3057\u305f\u60a3\u8005\u3055\u3093\u306f\u3001\u30a6\u30b4\u30fc\u30d3\u3092\u4f7f\u7528\u3057\u305f\u30b0\u30eb\u30fc\u30d7\u3067\u7d0462.9\uff05\u306b\u9054\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e\u7d0434.3\uff05\u3092\u5927\u304d\u304f\u4e0a\u56de\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001MASH\u3092\u60aa\u5316\u3055\u305b\u308b\u3053\u3068\u306a\u304f\u809d\u7dda\u7dad\u5316\u304c\u6539\u5584\u3057\u305f\u60a3\u8005\u3055\u3093\u3082\u7d0436.8\uff05\u3068\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3088\u308a\u6709\u610f\u306b\u9ad8\u3044\u5272\u5408\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306b\u3001MASH\u305d\u306e\u3082\u306e\u3060\u3051\u3067\u306a\u304f\u3001\u809d\u6a5f\u80fd\u3092\u793a\u3059ALT\u3084AST\u306e\u6539\u5584\u3001\u809d\u81d3\u306b\u305f\u307e\u3063\u305f\u8102\u80aa\u306e\u6e1b\u5c11\u3001\u7d0410\uff05\u306e\u4f53\u91cd\u6e1b\u5c11\u3001HbA1c\uff08\u8840\u7cd6\u5024\u306e\u6307\u6a19\uff09\u306e\u6539\u5584\u3001\u30a6\u30a8\u30b9\u30c8\u5468\u56f2\u5f84\u306e\u6e1b\u5c11\u306a\u3069\u3082\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u3053\u3068\u304b\u3089\u3001\u30a6\u30b4\u30fc\u30d3\u306f\u809d\u81d3\u3060\u3051\u3067\u306a\u304f\u3001MASH\u306e\u539f\u56e0\u3068\u306a\u308b\u80a5\u6e80\u3084\u7cd6\u4ee3\u8b1d\u7570\u5e38\u306a\u3069\u306e\u6539\u5584\u306b\u3082\u5f79\u7acb\u3064\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002(<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40305708\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/pubmed.ncbi.nlm.nih.gov\/40305708<\/a>) <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u526f\u4f5c\u7528\u3068\u3057\u3066\u306f\u3001\u5410\u304d\u6c17\u3084\u5614\u5410\u3001\u4e0b\u75e2\u3001\u4fbf\u79d8\u306a\u3069\u306e\u6d88\u5316\u5668\u75c7\u72b6\u304c\u6bd4\u8f03\u7684\u591a\u304f\u307f\u3089\u308c\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u305d\u306e\u591a\u304f\u306f\u8efd\u5ea6\u304b\u3089\u4e2d\u7b49\u5ea6\u3067\u3001\u9069\u5207\u306b\u5897\u91cf\u3057\u306a\u304c\u3089\u6cbb\u7642\u3092\u7d9a\u3051\u308b\u3053\u3068\u3067\u3001\u591a\u304f\u306e\u60a3\u8005\u3055\u3093\u304c\u6cbb\u7642\u3092\u7d99\u7d9a\u3067\u304d\u305f\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>MASH\u306f\u8840\u6db2\u691c\u67fb\u3060\u3051\u3067\u306f\u8a3a\u65ad\u3067\u304d\u307e\u305b\u3093<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u5065\u5eb7\u8a3a\u65ad\u3067\u300c\u8102\u80aa\u809d\u304c\u3042\u308a\u307e\u3059\u300d\u3068\u6307\u6458\u3055\u308c\u305f\u3053\u3068\u304c\u3042\u308b\u65b9\u306f\u5c11\u306a\u304f\u3042\u308a\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001\u8102\u80aa\u809d\u304c\u3042\u308b\u3060\u3051\u3067\u306fMASH\u3068\u306f\u8a3a\u65ad\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001AST\u3084ALT\u306a\u3069\u306e\u809d\u6a5f\u80fd\u306e\u6570\u5024\u304c\u6b63\u5e38\u3067\u3082MASH\u304c\u96a0\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u3042\u308a\u3001\u9006\u306b\u3053\u308c\u3089\u306e\u6570\u5024\u306b\u7570\u5e38\u304c\u3042\u3063\u3066\u3082MASH\u3067\u306f\u306a\u3044\u5834\u5408\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u73fe\u5728\u306eMASH\u8a3a\u7642\u3067\u306f\u3001\u8102\u80aa\u809d\u304c\u3042\u308b\u304b\u3069\u3046\u304b\u3060\u3051\u3067\u306a\u304f\u3001\u809d\u81d3\u306e\u7dda\u7dad\u5316\uff08\u809d\u81d3\u304c\u786c\u304f\u306a\u308b\u3053\u3068\uff09\u304c\u3069\u306e\u7a0b\u5ea6\u9032\u3093\u3067\u3044\u308b\u304b\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u304c\u975e\u5e38\u306b\u91cd\u8981\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5b9f\u969b\u3001\u5c06\u6765\u7684\u306a\u809d\u786c\u5909\u3084\u809d\u7d30\u80de\u304c\u3093\u306e\u30ea\u30b9\u30af\u306f\u3001\u809d\u81d3\u306b\u305f\u307e\u3063\u305f\u8102\u80aa\u306e\u91cf\u3088\u308a\u3082\u3001\u7dda\u7dad\u5316\u306e\u9032\u307f\u5177\u5408\u3068\u5f37\u304f\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u305f\u3081\u3001\u8840\u6db2\u691c\u67fb\u306f\u8a3a\u65ad\u306e\u7b2c\u4e00\u6b69\u3068\u3057\u3066\u91cd\u8981\u3067\u3059\u304c\u3001\u305d\u308c\u3060\u3051\u3067MASH\u3092\u78ba\u5b9a\u8a3a\u65ad\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd1\u5e74\u3067\u306f\u3001FIB-4 index\u3068\u3044\u3046\u6307\u6a19\u304c\u5e83\u304f\u5229\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u5e74\u9f62\u3001AST\u3001ALT\u3001\u8840\u5c0f\u677f\u6570\u306e4\u9805\u76ee\u304b\u3089\u8a08\u7b97\u3057\u3001\u809d\u7dda\u7dad\u5316\u306e\u53ef\u80fd\u6027\u3092\u7c21\u5358\u306b\u8a55\u4fa1\u3067\u304d\u308b\u305f\u3081\u3001MASH\u304c\u7591\u308f\u308c\u308b\u60a3\u8005\u3055\u3093\u3092\u898b\u3064\u3051\u308b\u305f\u3081\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u691c\u67fb\u3068\u3057\u3066\u591a\u304f\u306e\u533b\u7642\u6a5f\u95a2\u3067\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001FIB-4 index\u306f\u3042\u304f\u307e\u3067\u3082\u300c\u809d\u7dda\u7dad\u5316\u306e\u53ef\u80fd\u6027\u300d\u3092\u63a8\u5b9a\u3059\u308b\u305f\u3081\u306e\u6307\u6a19\u3067\u3059\u3002\u5e74\u9f62\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u304f\u3001\u9ad8\u9f62\u8005\u3067\u306f\u5b9f\u969b\u3088\u308a\u9ad8\u304f\u3001\u82e5\u3044\u65b9\u3067\u306f\u9032\u884c\u3057\u305f\u7dda\u7dad\u5316\u304c\u3042\u3063\u3066\u3082\u4f4e\u304f\u51fa\u308b\u3053\u3068\u304c\u3042\u308b\u305f\u3081\u3001\u3053\u306e\u691c\u67fb\u3060\u3051\u3067MASH\u3092\u8a3a\u65ad\u3057\u305f\u308a\u3001\u6cbb\u7642\u3092\u958b\u59cb\u3057\u305f\u308a\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u6700\u9069\u4f7f\u7528\u63a8\u9032\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306f\u5c02\u9580\u7684\u306a\u7dda\u7dad\u5316\u8a55\u4fa1\u304c\u5fc5\u8981<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u30a6\u30b4\u30fc\u30d3\u306f\u3001MASH\u3068\u8a3a\u65ad\u3055\u308c\u305f\u3059\u3079\u3066\u306e\u65b9\u304c\u4f7f\u7528\u3067\u304d\u308b\u85ac\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u9069\u6b63\u306b\u4f7f\u7528\u3059\u308b\u305f\u3081\u3001\u539a\u751f\u52b4\u50cd\u7701\u306f\u300c\u6700\u9069\u4f7f\u7528\u63a8\u9032\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u300d\u3092\u5b9a\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306f\u3001\u6cbb\u7642\u306e\u5bfe\u8c61\u3068\u306a\u308b\u306e\u306f\u3001\u809d\u786c\u5909\u3092\u4f34\u308f\u306a\u3044MASH\u3067\u3001\u4e2d\u7b49\u5ea6\u304b\u3089\u9ad8\u5ea6\u306e\u809d\u7dda\u7dad\u5316\uff08F2\uff5eF3\uff09\u304c\u78ba\u8a8d\u3055\u308c\u305f\u60a3\u8005\u3055\u3093\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u305f\u3081\u3001\u5065\u5eb7\u8a3a\u65ad\u3067\u300c\u8102\u80aa\u809d\u304c\u3042\u308a\u307e\u3059\u300d\u3068\u6307\u6458\u3055\u308c\u305f\u308a\u3001\u8840\u6db2\u691c\u67fb\u3067AST\u3084ALT\u304c\u9ad8\u304b\u3063\u305f\u308a\u3059\u308b\u3060\u3051\u3067\u306f\u3001\u30a6\u30b4\u30fc\u30d3\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5b9f\u969b\u306b\u30a6\u30b4\u30fc\u30d3\u306e\u6cbb\u7642\u3092\u958b\u59cb\u3059\u308b\u306b\u306f\u3001\u8d85\u97f3\u6ce2\u30a8\u30e9\u30b9\u30c8\u30b0\u30e9\u30d5\u30a3\uff08FibroScan\u306a\u3069\uff09\u3001MR\u30a8\u30e9\u30b9\u30c8\u30b0\u30e9\u30d5\u30a3\u3001\u307e\u305f\u306f\u809d\u751f\u691c\u306b\u3088\u3063\u3066\u3001\u4e2d\u7b49\u5ea6\u4ee5\u4e0a\uff08F2\u4ee5\u4e0a\uff09\u306e\u809d\u7dda\u7dad\u5316\u304c\u78ba\u8a8d\u3055\u308c\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 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class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u305f\u3081\u539a\u751f\u52b4\u50cd\u7701\u306e\u6700\u9069\u4f7f\u7528\u63a8\u9032\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306f\u3001MASH\u306b\u5bfe\u3059\u308b\u30a6\u30b4\u30fc\u30d3\u306f\u809d\u75be\u60a3\u8a3a\u7642\u306b\u5341\u5206\u306a\u7d4c\u9a13\u3092\u6709\u3059\u308b\u533b\u5e2b\u3084\u5c02\u9580\u65bd\u8a2d\u306e\u3082\u3068\u3067\u4f7f\u7528\u3059\u308b\u3053\u3068\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u5f53\u30af\u30ea\u30cb\u30c3\u30af\u3067\u3067\u304d\u308b\u3053\u3068<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u5f53\u30af\u30ea\u30cb\u30c3\u30af\u3067\u306f\u3001\u7cd6\u5c3f\u75c5\u3084\u8102\u8cea\u7570\u5e38\u75c7\u3001\u80a5\u6e80\u75c7\u306a\u3069\u306e\u751f\u6d3b\u7fd2\u6163\u75c5\u3092\u4e2d\u5fc3\u306b\u8a3a\u7642\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u304c\u3001MASH\u306b\u5bfe\u3059\u308b\u30a6\u30b4\u30fc\u30d3\u306e\u51e6\u65b9\u306f\u884c\u3063\u3066\u304a\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p 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class=\"wp-block-paragraph\">\u6cbb\u7642\u3092\u958b\u59cb\u3059\u308b\u306b\u306f\u3001\u8d85\u97f3\u6ce2\u30a8\u30e9\u30b9\u30c8\u30b0\u30e9\u30d5\u30a3\u3084MR\u30a8\u30e9\u30b9\u30c8\u30b0\u30e9\u30d5\u30a3\u306a\u3069\u306b\u3088\u308b\u809d\u7dda\u7dad\u5316\u306e\u8a55\u4fa1\u304c\u5fc5\u8981\u3067\u3042\u308a\u3001\u7d99\u7d9a\u7684\u306a\u5c02\u9580\u8a3a\u7642\u3082\u91cd\u8981\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3067\u3001\u5065\u5eb7\u8a3a\u65ad\u3067\u8102\u80aa\u809d\u3092\u6307\u6458\u3055\u308c\u305f\u65b9\u3084\u3001\u7cd6\u5c3f\u75c5\u30fb\u8102\u8cea\u7570\u5e38\u75c7\u30fb\u80a5\u6e80\u75c7\u306a\u3069\u304c\u3042\u308aMASH\u304c\u7591\u308f\u308c\u308b\u65b9\u306b\u3064\u3044\u3066\u306f\u3001\u5f53\u30af\u30ea\u30cb\u30c3\u30af\u3067\u8840\u6db2\u691c\u67fb\u306a\u3069\u306e\u521d\u671f\u8a55\u4fa1\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u7d50\u679c\u3001MASH\u3084\u809d\u7dda\u7dad\u5316\u304c\u7591\u308f\u308c\u308b\u5834\u5408\u306b\u306f\u3001\u8d85\u97f3\u6ce2\u30a8\u30e9\u30b9\u30c8\u30b0\u30e9\u30d5\u30a3\u306a\u3069\u306e\u5c02\u9580\u7684\u306a\u691c\u67fb\u3084\u6cbb\u7642\u304c\u53ef\u80fd\u306a\u533b\u7642\u6a5f\u95a2\u3092\u3054\u7d39\u4ecb\u3057\u3001\u9069\u5207\u306a\u8a3a\u65ad\u30fb\u6cbb\u7642\u306b\u3064\u306a\u3052\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u4eca\u5f8c\u671f\u5f85\u3055\u308c\u308bMASH\u6cbb\u7642<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">MASH\u306f\u4e16\u754c\u4e2d\u3067\u60a3\u8005\u6570\u304c\u5897\u52a0\u3057\u3066\u304a\u308a\u3001\u300c\u6b21\u306e\u751f\u6d3b\u7fd2\u6163\u75c5\u300d\u3068\u3082\u547c\u3070\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u73fe\u5728\u3082\u4e16\u754c\u4e2d\u3067\u65b0\u3057\u3044\u6cbb\u7642\u85ac\u306e\u958b\u767a\u304c\u6d3b\u767a\u306b\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3059\u3067\u306b\u627f\u8a8d\u3055\u308c\u3066\u3044\u308bGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306b\u52a0\u3048\u3001GIP\/GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3084FGF21\u88fd\u5264\u3001\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u53d7\u5bb9\u4f53\u03b2\uff08THR-\u03b2\uff09\u4f5c\u52d5\u85ac\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u4f5c\u7528\u3092\u3082\u3064\u85ac\u5264\u304c\u81e8\u5e8a\u8a66\u9a13\u3067\u691c\u8a0e\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001\u30a8\u30d5\u30eb\u30ad\u30b7\u30d5\u30a7\u30eb\u30df\u30f3\uff08efruxifermin\uff09\u3001\u30da\u30b4\u30b6\u30d5\u30a7\u30eb\u30df\u30f3\uff08pegozafermin\uff09\u3001\u30e9\u30cb\u30d5\u30a3\u30d6\u30e9\u30ce\u30fc\u30eb\uff08lanifibranor\uff09\u306a\u3069\u3082\u6709\u671b\u306a\u6cbb\u7642\u85ac\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u3066\u304a\u308a\u3001\u4eca\u5f8c\u6570\u5e74\u9593\u3067MASH\u306e\u85ac\u7269\u7642\u6cd5\u306f\u3055\u3089\u306b\u5927\u304d\u304f\u9032\u6b69\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p 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